Colleton County High School is a public high school in Walterboro, South Carolina. It is the only public high school in Colleton County and is one of the largest high schools by enrollment in the state, despite being located in a mostly rural county. The school has a population of 1,497 students, in grades 9-12. It has a student teacher ratio of 23 to 1. The school is a part of the Colleton County School District.